Abstract:Medical Microbiology is the core discipline in clinical medicine, which features sound theoretical basis and feasible applicability. In response to the requirements for medical talents, the reform of Medical Microbiology should highlight the competence and quality training of students based on the learning-centered teaching philosophy. According to the results of learning situation analysis, flipped classroom, integration of ideological and political elements, problem-based learning (PBL), virtual simulation experiment, clinical probation, and open experiment were adopted for the teaching reform. The practice results indicated that the reform system allowed the course to serve medical talent training, mobilize the enthusiasm of students, improved students' innovation ability and service consciousness, and achieved a win-win situation between teachers and students, thereby realizing the teaching goal.