Early clinical exposure to enhance the understanding of the role of a doctor is the main direction of higher medical education reform in China in the 21st century. Based on the shortcomings of the current teaching model of Medical Microbiology in the 5-year clinical medicine program, we have reformed both theoretical and practical teaching by adding theoretical classes, discussion classes, and noviciate aligned with the concept of "early clinical exposure". Thereby, we constructed the "early clinical exposure" teaching mode suitable for this discipline. The teaching effectiveness was evaluated by final examination and questionnaire survey. The results showed that "early clinical exposure" teaching mode can effectively integrate basic theories and clinical practices, stimulate the learning motivation of students, and improve their academic performance and comprehensive analytical skills to a certain extent while deepening their understanding of medicine and profession.