Abstract:Using innovated teaching method in classroom teaching facilitates the innovation of the ideological and political education in colleges and universities. We reform the teaching mode of Microbiology by adopting large-class teaching and small-class tutoring, emphasizing process assessment, combining theory imparting with experiment teaching and innovation practice. Through the introduction of typical education cases, representative inspirational stories, and examples of scientific and technological innovation in China, knowledge is combined with ideological and political elements in the teaching of Microbiology. The practice indicates that the reformed course cultivates the autonomous learning ability and consolidates the professional foundation of students, improving the teaching performance. It improves students' scientific literacy, practical ability and comprehensive quality and enhances students' self-confidence, sense of mission and patriotism, thus integrating knowledge imparting, ability training and value guidance.