Abstract:In recent years, a large number of blended courses have emerged under the background of developing "first-class courses" (Ministry of Education). Through the research and analysis of courses for undergraduates in the past decade, and via the advantages of information engineering in the science and engineering universities, we developed a "five-in-one" blended teaching system for the course of Microbiology suited to the "Internet+" era. Based on the reconstruction of the characteristic content of the emerging engineering, it effectively integrated life science into engineering courses. Then, with multi-dimensional information resources, it provided students with hierarchical and diversified choices. The advanced offline teaching activities laid a foundation for the scientific research and innovation ability of students. The systematic ideological and political education in the course helped students develop correct values. Finally, big data was used for formative teaching evaluation, ensuring the personalized learning quality of students in the whole process. Based on the continuous reform and practices, we have made major headway.