Abstract:The course of Modular Microbiology Experiments of our university is among the first batch of national online first-class courses. Outstanding teaching team, excellent offline courses, innovative teaching method, and ideological and political education are the four core elements of first-class curriculum construction. To be specific, firstly, we held teaching seminars, prepared lessons, set up a WeChat group for communication, applied for teaching reform projects, wrote papers on the reform, compiled teaching materials, and participated in teaching competitions. In doing so, we established a teaching team with high teaching level, strong desire for teaching reform, and good division of labor and cooperation. Secondly, the offline curriculum system was built according to the first-class course standard. We tailored the course into a comprehensive and research-based experimental course in modular form. As a result, the curriculum was characterized by modular content, inquiry-based learning, and comprehensive experimental technologies. Thirdly, we strengthened the ideological and political education by integrating patriotism, scientist spirit, sense of adherence to academic norms, and social responsibility consciousness. Fourthly, in classroom teaching, we used case teaching method, inquiry-based teaching method, and competition instead of practice to help students to master experimental technologies, improve analytical ability, and develop scientific literacy.