Abstract:Virtual reality experiment is an important approach of modern intelligent teaching, improving the teaching quality in medical colleges and universities. We developed the virtual reality experiment on the detection and control of Vibrio cholerae, which not only made up for the experimental teaching that cannot be carried out due to biosafety issues, but also solved the problem of operation standardization in the teaching of microbiology experiments. The blended three-step teaching model was adopted to realize the student-centered teacher-student interaction. A design-based experiment report combined with education elements was created to cultivate medical students' sense of professional mission. The assessment standards were refined to realize the evaluation of process. We explored the blended experimental teaching model composed of pre-class inspiration, in-class assimilation, and post-class consolidation and extension to improve the experimental skills of students and achieve the goal of co-education of knowledge (literacy) and practice (ability).