Abstract:Flipped classroom is an important approach to realize student-centered teaching and improve students' autonomous learning ability. With the development of online courses and learning platform technology, students can get enough resources before class. However, the students who are used to cramming method still lack the motivation and method of independent learning. Therefore, our team tried to use the classroom activity design of scenario simulation to address the difficulties in the implementation of flipped classroom. We found that writing scripts according to clinical cases can improve students' interest and ability of self-study, which significantly increased the online preview time, chapter visits, reading rate of reference materials, and group discussion time. In class, the knowledge learned before class was practiced, which promoted the interaction between teachers and students, helped students deepen their understanding, improved the test score and course satisfaction, and cultivated the teamwork spirit, clinical thinking, and professional ability of students. Therefore, the integration of scenario simulation facilitates the realization of the closed loop of pre-class learning and in-class learning in flipped classroom teaching. This teaching attempt will provide reference for further development of flipped classroom.