Abstract:Research-oriented teaching is an innovative teaching model focusing on students' development, and the purpose coincides with the goal of "golden course" development that emphasizes the cultivation of students' research skills and inspiration of their creativity. In the process of building leading curricula for Microbiology, we combined research-oriented teaching philosophy and BOPPPS teaching mode, and added the "improvement" module and ideological and political materials to establish a problem-driven modular closed-loop teaching model of introduction-objective-pre-test- participatory learning-post-test-improvement-summary (seven-step method) focusing on scientific frontier. The model can effectively improve the logicality and organization of classroom teaching, teaching efficiency, and the ability of students to analyze and solve problems. It lays a solid foundation for students to conduct scientific research in the future and provides a reference for developing "golden course" courses centering on students.