Abstract:The advent of new technologies in the internet era challenged the traditional teaching model. With the concept that teaching and learning are of equal importance, we explored and practiced the "SPOC+PAD class" blended teaching model in Microbiology courses at Shenzhen University. We reconstructed the teaching content according to pre-class, in-class, and after-class modules, and designed and separated each teaching module into five sections:presentation-assimilation-review-discussion- presentation (P-A-R-D-P). SPOC was used in the first P-A sections, and PAD class was used in the following R-D-P sections. Such teaching reform can neither ignore the importance of systematical teaching in traditional classes nor let the students learn completely by themselves. This blended teaching model creates an interactive classroom atmosphere that is fully designed by teachers and fully participated by students and is conducive to achieving a dynamic balance between "teaching" and "learning" as well as between "power" and "responsibility". The first period of teaching reform practice has been fully affirmed by students and achieved high teaching satisfaction.