Abstract:Industrial Microbiology, a core course of life sciences, features high applicability. In order to achieve the training of applied talent in local universities, the teaching team actively combined with the development of local industrial characteristics to reform the applied teachers training, reorganize the teaching content, construct the online and offline blended and social practice teaching model, and establish a formative learning evaluation system. The practice indicated that the reformed curriculum teaching could stimulate students' internal learning motivation, effectively improved students' application ability and comprehensive quality, and finally achieved good effects.