假单胞菌属双组分信号转导系统调控吩嗪生物合成研究进展

Research progress on phenazine biosynthesis regulated by two-component signal transduction system of Pseudomonas aeruginosa

摘要:

吩嗪是由假单胞菌或链霉菌产生的一类具有抗菌、抗肿瘤和抗寄生虫活性的含氮杂环代谢物，在农业和医疗领域具有广泛的应用。但吩嗪的合成受到复杂的级联网络调控。本文总结了假单胞菌属中双组分信号转导系统（two-component signal transduction system，TCS）对吩嗪生物合成的调控机制，阐明在双组分信号转导系统的控制下小RNA （small RNA）和群体感应（quorum sensing）对吩嗪生物合成的影响，为假单胞菌属调控吩嗪合成级联网络的进一步研究提供参考。

Abstract:

Phenazine is a class of nitrogen-containing heterocyclic compounds. It is usually a secondary metabolite produced by Pseudomonas or Streptomyces. Phenazine has antibacterial activity, and phenazine also has anti-insect and anti-tumor activity. It is not only widely used in agriculture, but also widely used in medical field. But the synthesis of phenazine is very complex, because it is regulated by a multi-cascade network. In this article, the author will summarize the regulatory mechanism of two-component signal transduction system on phenazine biosynthesis in Pseudomonas. This paper elucidates the effect of small RNA on phenazine biosynthesis under the control of each two-component signal transduction system, and the effect of quorum sensing on phenazine biosynthesis under the control of each two-component signal transduction system. The purpose of this study is to provide a reference for the further study of the cascade network of phenazine synthesis regulated by Pseudomonas.