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假单胞菌属双组分信号转导系统调控吩嗪生物合成研究进展
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黑龙江省自然科学基金重点项目(ZD2020C008)


Research progress on phenazine biosynthesis regulated by two-component signal transduction system of Pseudomonas aeruginosa
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    摘要:

    吩嗪是由假单胞菌或链霉菌产生的一类具有抗菌、抗肿瘤和抗寄生虫活性的含氮杂环代谢物,在农业和医疗领域具有广泛的应用。但吩嗪的合成受到复杂的级联网络调控。本文总结了假单胞菌属中双组分信号转导系统(two-component signal transduction system,TCS)对吩嗪生物合成的调控机制,阐明在双组分信号转导系统的控制下小RNA (small RNA)和群体感应(quorum sensing)对吩嗪生物合成的影响,为假单胞菌属调控吩嗪合成级联网络的进一步研究提供参考。

    Abstract:

    Phenazine is a class of nitrogen-containing heterocyclic compounds. It is usually a secondary metabolite produced by Pseudomonas or Streptomyces. Phenazine has antibacterial activity, and phenazine also has anti-insect and anti-tumor activity. It is not only widely used in agriculture, but also widely used in medical field. But the synthesis of phenazine is very complex, because it is regulated by a multi-cascade network. In this article, the author will summarize the regulatory mechanism of two-component signal transduction system on phenazine biosynthesis in Pseudomonas. This paper elucidates the effect of small RNA on phenazine biosynthesis under the control of each two-component signal transduction system, and the effect of quorum sensing on phenazine biosynthesis under the control of each two-component signal transduction system. The purpose of this study is to provide a reference for the further study of the cascade network of phenazine synthesis regulated by Pseudomonas.

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邱薇,刘磊,康杰,叶泽铭,葛菁萍. 假单胞菌属双组分信号转导系统调控吩嗪生物合成研究进展[J]. 微生物学通报, 2022, 49(1): 352-362

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  • 收稿日期:2021-05-10
  • 最后修改日期:
  • 录用日期:2021-07-08
  • 在线发布日期: 2021-12-30
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