Abstract:A white-rot basidiomycete Ganoderma spp. is a rare edible and medicinal fungus, which is rich in a variety of bioactive components. Liquid fermentation technology has the advantages of short production cycle, high efficiency, high yield and stable quality, which is an important way to develop and utilize Ganoderma resources. In recent years, great progress has been made in the development and application of liquid fermentation of mycelia of Ganoderma species. In this paper, the main active components and medicinal effects of liquid fermentation products of Ganoderma spp., the optimization of liquid fermentation process and the application of fermentation products were reviewed, and the future of this field was prospected.