Abstract:In view of the emerging biosafety and bioethics issues in recent years, the teaching of biosafety and bioethics for students majoring in biotechnology is worthy of research and discussion. Small-sized class teaching represents a new measure of teaching reform in China’s colleges and universities in recent years, which is flexible and specific, increases the interactivity between teachers and students, and contributes to the improvement of teaching quality. Considering the characteristics of biosafety and bioethics course in biotechnology specialty and the practice of small-sized class teaching, this paper discusses the teaching experience of small-sized class, analyzes the shortcomings, and puts forward some suggestions for improvement.