Abstract:The toxin-produing Bacillus cereus is among the common foodborne pathogens. It elicits two types of gastrointestinal illness: vomiting and diarrhoeal syndrome, and causes a variety of local and systemic infections. Due to the extensive use of antibiotics, the resistance of B. cereus has been enhanced, and multiple-antibiotic resistance has been reported. To gain a clear insight into the characteristics and rules of the antibiotic resistance of B. cereus, this paper reviewed the resistance status quo and the mechanism, which is expected to lay a theoretical basis for prevention and control of antibiotic resistance of the bacteria and rational use of antibiotics.