结直肠癌相关致病菌的研究进展

Research progress of colorectal cancer related pathogens bacteria

摘要:

肠道微生物群落与结直肠癌（Colorectal Cancer，CRC）有着十分密切的关系。肠道微生物的群落变化可能会伴随着CRC的发生，而一些有害菌的出现可能是导致CRC的直接原因。其中，具核梭杆菌（Fusobacterium nucleatum）、产肠毒素脆弱拟杆菌（Enterotoxigenic Bacteroides fragilis，ETBF）和pks阳性大肠杆菌（pks⁺ Escherichia coli）与CRC的发生最密切。本综述着重介绍了pks⁺ E. coli及Colibactin的致病原因、对肠道微生物组成的影响、Colibactin的合成及怎样抑制或促进pks⁺ E. coli。同时也对ETBF和F. nucleatum可能的致癌原因、对肠道微生物组成的影响及对二者的促进或抑制做出了介绍。

Abstract:

Intestinal microbiota is closely related to colorectal cancer (CRC). The change of intestinal microbial community may be accompanied by the occurrence of CRC, and the emergence of some harmful bacteria may be the direct cause of CRC. Among them, Fusobacterium nucleatum (F. nucleatum), enterotoxigenic Bacteroides fragilis (ETBF) and pks⁺ Escherichia coli (pks⁺ E. coli) were most closely associated with CRC. This review focuses on the pathogenic causes of pks⁺ E. coli and colibactin, the effects on intestinal microbial composition, the synthesis of colibactin and how to inhibit or promote pks⁺ E. coli. At the same time, the possible carcinogenic causes of ETBF and F. nucleatum, their effects on intestinal microbial composition and their promotion or inhibition were also introduced.