抗肠道病毒71型的药物研究进展

Recent progress towards enterovirus 71 about antiviral agents

摘要:

肠道病毒71型（Enterovirus 71，EV71）是引起重症手足口病（Hand，Foot and Mouth Disease，HFMD）的主要病原体。重症HFMD进展迅速，可表现为严重的神经系统并发症，甚至危及生命。目前临床上防治EV71感染缺乏特异、高效的药物，其残疾率和死亡率很高。随着研究的深入，已经发现了大量具有抗EV71能力的化合物，人们探索的药物机制和药物靶点各不相同。因此，本文从药物靶向病毒、宿主等角度出发，针对抗EV71感染的天然药物、合成药物及常见中药中活性成分作用机制的最新进展进行综述与讨论。此外，对抗病毒药物筛选技术进行简要概述，以期为抗EV71药物的筛选与研发设计等相关研究提供参考。

Abstract:

Enterovirus 71 (EV71) belonging to human enterovirus, is the mainly causative agent of severe Hand, Foot and Mouth Disease (HFMD) and has been associated with various neurological complications, even death. There is currently no effective prevention and specific therapy for EV71, following high disability and mortality rates. Along with the profound study, a large number of compounds with anti-EV71 ability have been discovered, and the mechanisms and drug targets explored are different. Thus, from the perspective of drug to virus and host, this paper reviews and discusses the latest progress in the mechanism of active ingredients in natural drugs, synthetic drugs and common traditional Chinese medicine against EV71 infection. In addition, the screening technology of anti-EV71 drugs was briefly summarized, aiming to provide help for the screening, research and development of anti EV71 drugs.