Abstract:Online and offline blended teaching had become a new teaching mode adopted by many college course under the normalized epidemic prevention and control. Combining the advantages of LBL teaching and MOOC teaching, the course team re-constructed the online teaching process of Fermentation Engineering course with student as the center, and a series of reform and exploration were carried out on the teaching objectives, teaching requirements, teaching chapters, teaching assessment, teaching methods and so on. Meanwhile, the course team tried to turn the online flipped classroom and the ideological and political education integration into the classroom teaching mode, the students' enthusiasm for autonomous learning had been improved, and it also promoted and improved the teaching and learning effect of course teaching.