Abstract:In response to the appeal of the Ministry of Education about "golden curriculum construction", we took "student-centered" and "competence development" as the fundamental goal and task of the teaching reform. Our reform on teaching of Microbiology introduced modern education methods and adopted "online and offline blended" teaching mode. Online mode includes:(1) Providing all resources related to course teaching via Superstar Fanya network teaching platform with resources such as basic resources, auxiliary resources and development resources for students to study outside class; chapter teaching design consisting of self-study outline, famous teacher MOOCs, teaching interaction and homework exercises for students' self-study before class, interaction in class and review after class; stage questionnaire and suggestions for teaching evaluation and reflection. (2) Achieving the real-time interactive communication between teacher and students in and out of class via the "Learning Link" mobile app, including task arrangement, learning assessment, question and answer, teaching interaction and course feedback, etc. Offline mode includes:Taking class teaching as the carrier, based on students' online learning situation and teaching design, we took class teaching as the carrier to adopt the following methods:classified teaching for different types of knowledge, and a variety of interactive teaching methods. By doing so we consolidate the outcome of self-teaching, strengthen the key points, analyze the difficult points, then consolidate the foundation and develop students' capability at the same time. The results showed that all students recognized the methods and effects of the teaching reform. They felt that the goal of teaching reform is clear, the emphasis is prominent and the methods are optimized. The adoption of the teaching reform can inspire thinking, stimulate interest, effectively improve class participation, enhance subjective initiative, and improve their competence comprehensively.