短链脂肪酸调控骨代谢的作用及机制的研究进展

The role of short-chain fatty acids in regulating bone metabolism and the mechanism: a review

摘要:

肠道菌群紊乱可导致宿主病理性骨质流失，其通过产生的代谢物从肠道扩散到体循环对骨代谢发挥重要的调控作用。短链脂肪酸（Short Chain Fatty Acids，SCFAs）是肠道细菌产生的代谢物家族中最受关注的代谢产物，近年来研究表明，SCFAs在骨代谢相关疾病的发生发展中具有重要调节作用。本文就其在骨骼系统中的作用、调节骨组织中细胞的机制及作为靶点防治骨代谢疾病骨质疏松的研究进行综述，并为此新兴且具有前景的研究领域在未来的基础研究和转化研究提供展望。

Abstract:

The disturbance of gut microbiota contributes to pathological bone loss in the host, as the metabolites of it diffuse from the gut to the systemic circulation to regulate bone metabolism. Among the metabolites of gut bacteria, short-chain fatty acids (SCFAs) attract the most attention. Recent studies have shown that SCFAs play an important part in the prevention and treatment of bone metabolism-related diseases. This review focused on the role of SCFAs in the skeletal system, the mechanism of regulating cells in bone tissue, and the functions in the prevention and treatment of osteoporosis, and summarized the future research directions.