Abstract:Microbiology is not only a significant branch of life science but also an important basic course for Biology, Food science, Clinical Medicine in university education. The course is comprehensive with a wide range of knowledge, so how to mobilize students' interest in learning effectively will affect the classroom effect directly. In order to achieve good teaching effectiveness, teachers could use a variety of ways to improve students' interest and learning quality in the process of teaching. In this article, we make teaching design by the "interesting teaching method", and make teaching reform for the same major's classes of three different grades in a row. The teaching achievements are verified according to the students' final evaluation, process assessment (including attendance rate, classroom participation, attention concentration and so on) and students' feedback comments. As the results, in the final evaluation, the failure rate from the students of the classes with "interesting teaching method" is lower and the proportions of "good" and "excellent" students are higher than which students without "interesting teaching method" class. Otherwise, the process assessment scores of teaching reformed classes are much higher than that without it, which indicates that the "interesting teaching method" reform mobilized the students' interest in learning effectively. Therefore, we think that teachers can properly lead interesting contents into teaching design and promote them during the Microbiology class, it will help to ameliorate teaching atmosphere, arouse the enthusiasm and initiative of students and improve teaching quality.