细菌群体感应系统与噬菌体的相互作用机制研究进展

Research progress on interactions between bacterial quorum sensing system and phage

摘要:

细菌在与噬菌体的长期共进化过程中形成多种抵抗噬菌体侵染的机制，其中群体感应参与的细菌抵御噬菌体侵染机制成为近年来的研究热点。群体感应与噬菌体之间的相互作用是复杂和多样的，本文将重点综述群体感应在噬菌体侵染中的作用、调控在噬菌体裂解-溶源转变的作用，以及群体感应与噬菌体的其他相互影响等内容，为噬菌体在细菌性疾病的治疗提供理论依据。

Abstract:

Bacteria possess a variety of resistant mechanisms against phage infection in the long-term coevolution with phages. Among them, quorum sensing has become a hot topic in recent years as a means for bacteria to resist phage infection. Bacterial quorum sensing mainly depends on bacterial density and regulates the expression of target genes, as well as the infection of phage. Therefore, bacterial quorum sensing is closely related to phage. However, the interactions between quorum sensing and phage are complex and diverse, quorum sensing has been proved to be unfavorable or beneficial to phage infection, and regulates the switch of phage lysis-lysogeny. Therefore, this paper will discuss the role of quorum sensing in phage infection, the decisive role of quorum sensing in phage lysis-lysogeny switch, and the other interactions between quorum sensing and phage, which provides theoretical basis for phage therapy in bacterial diseases.