噬菌体治疗肺炎克雷伯菌感染的研究进展

Advances in the treatment of Klebsiella pneumoniae infection with bacteriophage therapy

摘要:

肺炎克雷伯菌是肠杆菌科家族中的一员，在各种环境中广泛存在，可导致诸如奶牛乳房炎在内的多种动物疫病，引起人类的肺炎、尿路感染、菌血症、伤口性感染和化脓性脓肿在内的多种临床感染。该菌对抗生素的耐受日趋严重，而且高毒力菌株不断出现，给该菌的防控带来了巨大挑战。噬菌体是一种裂解细菌的病毒，因其具有治疗耐药细菌感染的潜力而备受关注，世界各地均有使用噬菌体成功治疗耐药细菌感染的案例。本文基于国内外对肺炎克雷伯菌及其噬菌体的研究数据，综述了肺炎克雷伯菌的流行病学调查情况和噬菌体在治疗肺炎克雷伯菌感染方面的应用，以期为基于肺炎克雷伯菌噬菌体的抗菌研究和临床应用提供参考。

Abstract:

Klebsiella pneumoniae is a member of the Enterobacteriaceae family and exists widely in a variety of environments. It can cause human and various animal diseases including mastitis, pneumonia, urinary tract infection, wound infection and lead to bacteremia and suppurative abscess, et al. Nowadays, the bacterial tolerance to antibiotics is becoming more and more serious, and the emergence of highly virulent strains has brought considerable challenges to the prevention and control of the bacteria. Bacteriophages are a group of viruses that can infect and kill host bacteria, have attracted much attention because of their potential to treat drug-resistant bacterial infections. Cases of successfully using bacteriophages to treat drug-resistant bacterial infections have been reported all over the world. Based on the research data of K. pneumoniae and its bacteriophage at home and abroad, this paper summarizes the epidemiological investigation of K. pneumoniae and the application of bacteriophage in the treatment of this bacterial infection, in order to provide references for authors in the antibacterial research and clinical application based on bacteriophage of K. pneumoniae.