影响微生物互作的重要基因研究进展：以大肠杆菌为例

Research progress in important genes affecting microbial interactions: take Escherichia coli as an example

摘要:

微生物在自然界中广泛存在，微生物间的相互作用对群落结构和功能有重要影响。目前已经对微生物相互作用的机制给予了很大的关注，通过高通量测序技术和统计学分析方法的结合可以定位获得影响菌株互作的重要基因。为了深入研究微生物相互作用的遗传机制，本文以大肠杆菌（Escherichia coli）为例，综述了与大肠杆菌运动性、耐药性、营养物质吸收和代谢调节相关的基因在互作条件下发挥的作用，并从这几个方面分别阐述了大肠杆菌互作遗传机制。总之，这些基因在大肠杆菌与其他微生物互作中发挥重要作用，同时增强了对细菌互作机制的理解，为今后研究更复杂的微生物群落互作遗传机制奠定了理论基础。

Abstract:

Microorganisms exist widely in nature, and the interactions between microorganisms have an important impact on community structure and function. At present, great attention has been paid to the mechanism of microbial interactions, and the important genes affecting the growth of an individual microorganism in the interactions have been identified by high-throughput genome sequencing and statistical analysis. In order to further study the genetic mechanism of microbial interactions, the role of genes related to motility, drug resistance, nutrient absorption and metabolic regulation in Escherichia coli under the interaction conditions was reviewed in this paper. The genetic mechanism of interactions among Escherichia coli and other microorganisms was discussed from these aspects. In general, these genes are very important for the survival of E. coli. These studies enhance our understanding of the mechanism of bacterial interactions, and lay a theoretical foundation for the future study of more complex genetic mechanisms of microbial community interactions.