细菌Cpx双组分信号转导系统应对外界环境变化的响应调节机制研究进展

Research progress of Cpx two-component system in bacteria

摘要:

细菌能够在其他微生物无法生存的环境中生长，必然具有更加强大的适应外界环境的能力。细胞信号转导的效率决定了细菌对外界刺激做出应答反应的速率和能力。双组分调控系统是维持细菌在压力环境中存活的重要结构。Cpx双组分信号转导系统是革兰氏阴性菌中普遍存在的双组分调控系统之一，在响应外界环境变化并做出适应性反应的过程中起着主要作用。本文主要针对细菌中双组分信号转导系统的种类、Cpx双组分信号转导系统参与的调控、Cpx双组分信号转导系统所调控的靶基因及其生理行为的研究进展进行综述，以期为科研人员更深入的研究提供思路和理论基础。

Abstract:

Bacteria can grow in the environment that other microorganisms can't survive, so it must have more powerful ability to adapt to the external environment. The efficiency of cell signal transduction determines the rate and ability of bacteria to respond to external stimulus. Two-component system is an important structure to maintain the survival of bacteria under conditions of stress. Two-component system Cpx is widely distributed in Gram-negative bacteria, which plays a major role in responding to the changes of external environment and making adaptive response. In this paper, the types of two-component signal transduction system in bacteria, the regulation of Cpx two-component system, the regulated target genes by Cpx two-component system and their physiological behavior were briefly reviewed to provide ideas and theoretical guidance for further research.