天然产物产生菌自抗性中DNA损伤修复的研究进展

Research progress on DNA damage repair in self-resistance of natural product producing bacteria

摘要:

临床上使用的抗生素大多是由微生物次级代谢产生的天然产物及其衍生物，这类化合物可以抑制微生物的生长，具有显著的细胞毒性。产生菌在合成这些抗生素的同时，也需要通过多种自抗性机制来应对其对自身的毒害作用。本文总结了近年来DNA损伤修复途径参与的天然产物产生菌自抗性机制的研究进展，重点介绍了DNA损伤类抗生素产生菌中的碱基切除修复途径和类核苷酸切除修复途径等，并对目前DNA损伤修复抗性机制中存在的问题进行了讨论，同时对其潜在的应用进行了展望。

Abstract:

Most of the antibiotics used to treat diseases are derived from natural products produced during microbial secondary metabolism. Given a strong cytotoxicity, the compound producers have to evolve effective self-resistance to avoid suicide when they synthesize these natural products. Herein, we review the recent research progress on DNA damage repair as a self-resistance strategy of natural product producing bacteria, especially those obtained from the base excision repair and nucleotide excision repair pathway in DNA damage antibiotics producers. Furthermore, the existing problems and the application perspective of the DNA damage repair mechanism in self-resistance are discussed.