微生物肽类次级代谢产物研究进展

Research progress on peptides produced by microorganisms

摘要:

微生物肽类次级代谢产物是一类重要的天然产物，因含有稀有氨基酸而具有丰富的化学结构和生物活性。随着微生物天然产物分离纯化技术的发展，新型肽类产物层出不穷，在微生物次级代谢产物的研究领域扮演了重要的角色。本文综述近年来发现的来自细菌和真菌的微生物肽类代谢产物，以及采用基因挖掘等手段人工合成的新型肽类产物，并结合近年来本团队昆虫病原线虫共生菌肽类产物的研究积累，分析微生物肽类产物研究存在的问题及可能的解决方案，以期为微生物导向的新型活性肽类产物的深入发掘和应用研究提供参考。

Abstract:

Microbial peptide secondary metabolites, which usually contain rare amino acids, are a series of natural products with rich chemical structures and biological activities. With the development of separation and purification technologies, a great number of new peptide products have been discovered, which play an important role in the exploration of microbial natural products. This paper reviews the microbial peptide metabolites from bacteria and fungi, as well as the new peptide products obtained by gene mining and other bioengineering methods in recent years. Combined with our team's research experiences of peptide products from entomopathogenic nematode symbiotic bacteria, this paper analyzes the existing problems and possible solutions in the research of microbial peptide products. We hope it could provide a reference for the further exploration and application of new active peptide products.