戊二酰亚胺类天然产物生物合成研究进展

Research progress of glutarimide-containing natural products biosynthesis

摘要:

微生物天然产物是天然药物的重要组成部分，而天然产物的良好生物活性很大程度上取决于发挥药效的结构基团。这些特殊药效基团的生物合成，通常是利用小分子羧酸、氨基酸等结构简单的初级代谢产物，经过复杂的生物化学过程，最终合成结构复杂活性多样的天然产物。戊二酰亚胺类天然产物是一类重要的细菌来源天然产物，它们具有良好的生物活性，是潜在的先导化合物，部分化合物已被开发成分子探针。本文综述了近年来微生物来源的戊二酰亚胺类天然产物及其生物合成研究，包括Iso-migrastatin、lactimidomyin、cycloheximide、streptimidone、gladiostatin、sesbanimide等，对戊二酰亚胺类天然产物的生物合成研究，将有效促进通过基因组挖掘策略寻找新型戊二酰亚胺类天然产物。

Abstract:

Microbial natural products are important component of natural product derived drugs, and the excellent biological activities of natural products mainly depend on the pharmacophore groups with special structures. The biosynthesis of these special pharmacophores usually uses small molecules, like carbohydrates, amino acids and other simple primary metabolites. After specific and complex biosynthetic pathways, the simple metabolites were assembled to synthesize natural products with complex structures and diverse activities. Glutarimide containing natural products are an important class of natural products isolated from bacteria. As the potential lead compounds, they show excellent biological activity and have been developed as molecular probes. This article reviews the glutarimide containing natural products isolated from microorganisms and related biosynthetic pathways characterized in recent years, including iso-migrastatin, lactimidomycin, cycloheximide, streptimidone, gladiostatin, sesbanimide. Based on the biosynthetic study of glutarimide moiety, we expect to identify more glutarimide containing natural products through genome mining strategies.