Abstract:Ideological and political education is an important form of carrying out the fundamental task of “educating people with moral cultivation” in colleges and universities. In the fight against the COVID-19 epidemic, the Chinese nation forged a great spirit of fighting the epidemic by pulling together in times of difficulty and helping each other. This provides the most vivid element for ideological and political education. In this article, we combed and summarized the spirit of fighting the COVID-19 epidemic, and condensed its connotation into five contents. This paper took the nucleic acid detection of the novel coronavirus, the anti-epidemic spirit contained in vaccine development and its mutation as the carrier of thinking and government, selected the corresponding theoretical content in the genetic engineering course, and carried out the ideological and political teaching design and practical research of the Genetic Engineering course focusing on the anti-epidemic spirit. This paper evaluated the teaching effect by using questionnaire method and in-depth interview method. The purpose of this study is to guide students to understand the spirit of fighting the COVID-19 epidemic contained in the course content, while learning professional theoretical knowledge, internalize it into value pursuit, and imperceptibly improve students’ ideological awareness and moral cultivation. Meanwhile, it can provide reference for the ideological and political education of other biological majors.