Abstract:The reversible phosphorylation modification of protein plays a crucial role in the life activities of fungal cells. The phosphorylation and dephosphorylation processes are coordinated with each other. The dephosphorylation of serine/threonine sites in protein is mainly catalyzed by protein phosphatase 2A (PP2A). The catalytic subunit, regulatory subunit and structural subunit are combined into an active trimeric holoenzyme form when PP2A is functioning. This article will take the model fungi Saccharomyces cerevisiae, Schizosaccharomyces cerevisiae, and the human conditional pathogen Candida albicans as examples to introduce the research progress of PP2A in fungal cells, helpful to understand the importance of dephosphorylation in regulating their life. In addition, we also analyzed the unclear problems in the research field of PP2A, and proposed possible research ideas.
