Abstract:The teaching model reform of the professional basic course of engineering specialty is crucial for the engineering education professional accreditation and the cultivation of applied talents. Taking the engineering education professional accreditation as an opportunity, in view of the shortcomings of the traditional teaching method under the background of the Internet, the teaching model of integration of problem-based learning (PBL) and small private online course (SPOC) was proposed based on the theoretical and practical characteristics of Food Microbiology. The problem introduction of pre-class, the problem intervention of inter-class and the problem feedback of after-class of the PBL and SPOC integrated teaching model, and the practical results had been analyzed and discussed. It provides reference for the improving independent learning ability and team cooperation consciousness, and the development of engineering education professional accreditation and engineering professional basic courses teaching in application-oriented local undergraduate universities.