线粒体自噬在感染性疾病中的作用机制研究进展

Mitophagy in infectious diseases: a review

摘要:

线粒体自噬作为一种选择性自噬方式是近年研究的热点。细胞通过自噬机制选择性清除受损伤或不必需的线粒体，从而维持其功能稳态。近年来，越来越多的研究聚焦于病原体通过胁迫线粒体自噬在机体感染过程中调节先天免疫信号通路，从而影响感染性疾病的进程。本文分别从线粒体自噬在病毒、细菌和真菌感染性疾病中的作用机制研究进展进行综述，以期为感染性疾病的防治提供新的指导策略。

Abstract:

As a selective form of autophagy, mitophagy has recently been considered as a research focus. It has been reported that mitophagy has a critical role in eliminating damaged or excessive mitochondria to maintain the cellular homeostasis. In recent years, accumulating studies have focused on mitophagy hijacked by pathogens in regulating innate immune signaling pathways to manipulate the course of infectious diseases. This article reviews the progress of mitophagy in the infectious diseases caused by virus, bacteria and fungi, aiming at providing a new reference for further strategies of prevention and treatment of infectious diseases.