肠道菌群改变与结核分枝杆菌感染相互作用的研究进展

Association of gut microbiota change with Mycobacteria tuberculosis infection: a review

摘要:

人体内肠道菌群数量庞大，参与机体物质代谢以及免疫应答反应，成为目前众多研究的热点。肠道菌群对于维持呼吸系统稳态，特别是肺部的稳态发挥着重要作用。目前越来越多的结果证明肠道菌群对机体免疫系统具有诱导和调节作用，这种免疫反应的改变对于结核病的发病和治疗有着深远意义。本文梳理了近年来国内外发表的肠道菌群与结核病相关的文献，讨论了结核分枝杆菌感染后肠道菌群的变化特征，分析肠道菌群对机体免疫应答的影响机制，探讨了饮食结构以及微生态制剂在结核病治疗过程中起到的作用，以期为有效预防和治疗结核病提供理论基础。

Abstract:

Large amount of gut microbiota (GM) in the human body participates in the body’s material metabolism and immune response reactions. Gut microbiota plays an important role in maintaining the steady state of the respiratory system, especially the lungs. Gut microbiota is closely related to the development of tuberculosis. After reviewing the literatures on the correlation of gut microbiota with tuberculosis, we discuss here the characteristics of gut microbiota after tuberculosis infection, analyze the mechanism of gut microbiota on the body’s immune response. Moreover, we also address the role of diet structure and microecological preparations in the treatment of tuberculosis to provide a theoretical basis for the effective prevention and treatment of tuberculosis.