Abstract:Fermentation Engineering is a core course with strong practicality and applicability of Bioengineering. Based on outcome-based education (OBE) concept of Engineering Education Accreditation, reasonable and specific course objectives of Fermentation Engineering were formulated, focusing on training students’ engineering knowledge, problem analysis, engineering design and research ability. Aiming at the achievement of course objectives, the teaching content, methods, design and implementation of different content modules were integrated and optimized, and diversified assessment methods were adopted focusing on formative evaluation of the course. The evaluation model of course objectives achievement was constructed and a closed-loop course quality assurance system of design-implementation-assessment-evaluation-improvement was formed. The teaching reform effectively improved students’ ability to understand, analyze, design and study fermentation engineering problems, also enhanced students’ scientific interest and innovation ability.