女性生殖系统微生物群落及其与早产相关性研究进展

Female reproductive system microbiome and its correlation with preterm birth: a review

摘要:

女性生殖系统微生物群落与女性生殖健康密切相关。阴道微生物的菌群变化伴随着多种阴道疾病的发生并可能通过宫颈感染子宫，孕期子宫内的炎症反应会导致胎儿早产(preterm birth，PTB)，PTB被定义为妊娠满28周但不足37周所发生的分娩现象，PTB婴儿死亡率很高并面临着多种健康疾病，除了明确病原微生物的感染，PTB还伴随着生殖系统微生物群落失衡，将来有望通过根据女性生殖系统微生物群落的动态变化来预防PTB的发生。本综述将着重介绍女性生殖系统微生物群落与生殖健康，尤其是与PTB之间的联系。

Abstract:

Microbiome of female reproductive system are closely related to female reproductive health. Vaginal microbial flora changes are associated with a variety of vaginal diseases and may inflect the uterus through the cervix, inflammatory response in the uterus during pregnancy can lead to preterm birth (preterm birth, PTB). PTB is defined as a delivery that occurs at 28 weeks but less than 37 weeks of gestation, PTB infant mortality rate is very high and is faced with a variety of health-disease, in addition to clear the infection of pathogenic microorganism, PTB accompanied by microbiome imbalances in reproductive system, it is hoped that PTB can be prevented according to the dynamic changes of female reproductive system microbiome in the future. This review will focus on the relationship between the female reproductive system microbiome and reproductive health, especially with PTB.