核定位信号及其在病毒感染机制中的研究进展

Research progress of nuclear localization signal in virus infection mechanism

摘要:

核定位信号介导的蛋白入核是细胞内信号传递网络中核内外物质信息交流的重要一环，绝大多数病毒蛋白进入细胞核均需要核质转运受体识别和结合入核蛋白携带的核定位信号序列。病毒蛋白的入核转运机制在病毒感染过程中起着至关重要的作用，对于病毒的复制、毒力具有重要意义，针对该机制的研究有利于新的抗病毒靶点的发现。本文对核定位信号的分类信息进行了总结，并对不同的核质转运受体及其介导的入核机制进行了比较分析，概述了病毒入核蛋白及其核定位信号在病毒感染机制中的研究发现。

Abstract:

Nuclear localization signal-mediated protein entry into the nucleus is an important part of information exchange between the nucleus and the nucleus in the intracellular signal transmission network. Most viral proteins enter the nucleus in premise of being recognized by nuclear transport receptors and bound to the nuclear localization signals carried by viral proteins. The mechanism of important protein transport into the nucleus plays a vital role in the process of viral infection, and is of great significance for virus replication and virulence. The research on this mechanism is conducive to the discovery of new antiviral targets. This paper summarized the classification information of nuclear localization signals so as to conduct an analysis on comparisons of different nuclear transport receptors and their mediated entry mechanisms, and to sketch out the discovery of viral protein and its nuclear localization signal in the mechanism of viral infection.