布鲁氏菌毒力因子研究进展

Virulence factors of brucella: a review

摘要:

布鲁氏菌是一种革兰氏阴性、兼性胞内寄生菌，可引起人畜共患病布鲁氏菌病。布鲁氏菌致病机制复杂，可通过表达多种毒力因子等方式躲避或抑制宿主免疫系统的攻击并发挥其对机体的致病效应，实现其在宿主体内的长期存活。因此，布鲁氏菌病易转化为慢性感染。本文对目前已发现的多种布鲁氏菌毒力因子相关研究进展进行综述，以期进一步认识布鲁氏菌病的致病机理，为布鲁氏菌病防治提供参考。

Abstract:

Brucella is a Gram-negative, intracellular parasitic bacterium that can cause zoonosis- brucellosis. The pathogenic mechanism of Brucella is complex. Brucella can evade or inhibit the attack of host immune system and exert its pathogenic effect on the body by expressing a variety of virulence factors, so as to achieve its long-term survival in the host. Therefore, brucellosis is easy to transform into chronic infection. This paper reviews the research progress of a variety of virulence factors of brucellosis, in order to further understand the pathogenic mechanism of brucellosis and provide reference for the prevention and treatment of brucellosis.