Abstract:Medical Microbiology is an important basic course for undergraduate students in traditional chinese medical universities. In view of the practical problems that affect teaching effect in the traditional theoretical teaching process, the “three-link integration & bilateral interactive” blended teaching model combining online and offline is developed using the Super Star Learning APP. The three learning links pre-class, class and after-school study are integrated through activities such as autonomous learning, free discussion among students, and instructor-student interactive teaching. Teachers and students communicate and interact throughout the whole process with each other. The effect of blended learning was studied by comparative method. The preliminary exploration showed that, compared to the traditional one, this teaching mode improved students’ engagement, test score and autonomous learning enthusiasm, which is more conductive to students’ understanding and mastery of knowledge. Therefore, in the course of medical microbiology in traditional Chinese medical universities, blended teaching model is worthy of further research and promotion.