细菌Ⅵ型分泌系统的调控与功能研究进展

Advances in regulation and function of the bacterial type VI secretion system

摘要:

VI型分泌系统(Type VI Secretion System，T6SS)是近年来研究较多的一种细菌分泌系统，广泛存在于革兰氏阴性菌中，在细菌的毒力、定殖、扩散及竞争遗传中发挥着重要的作用。本文综述了细菌T6SS的结构、调控以及生物学功能的最新研究进展，以期为基于T6SS的抗菌药物研制及细菌感染的诊断与防控提供新思路。

Abstract:

Type VI secretion system (T6SS) that widely exists in Gram-negative bacteria has been extensive studied in recent years. It plays important roles in the virulence, colonization, spread and competition inheritance of bacteria. This paper reviews the latest research progresses in the structure, regulation and biological function of T6SS. Hopefully, the review could inspire the development of antibacterial drugs based on T6SS and provide new thoughts for the diagnosis and control of bacterial infections.