幽门螺杆菌外膜囊泡研究进展

Progress of outer membrane vesicles derived from Helicobacter pylori

摘要:

幽门螺杆菌(Helicobacter pylori，HP)被认为是引起人类胃部疾病的元凶之一。外膜囊泡(Outer Membrane Vesicles，OMVs)是由细菌外膜自发脱落而形成的囊泡状结构，其具有细菌外膜多数成分，包括外膜蛋白、多糖、脂质以及其他蛋白组分。越来越多的研究正在关注外膜囊泡在幽门螺杆菌感染、发生、发展过程中的作用。同时，研究表明幽门螺杆菌外膜囊泡作为疫苗，在防治幽门螺杆菌感染中也展现了良好的应用潜力。因此，本综述总结了目前关于幽门螺杆菌外膜囊泡组成成分的研究，并讨论了外膜囊泡在幽门螺杆菌存活和致病机制中的作用，以及外膜囊泡在幽门螺杆菌感染治疗中发挥的作用。

Abstract:

Helicobacter pylori (H. pylori) infection is one of the factors that cause human gastric diseases. Outer membrane vesicles (OMVs) are vesicular structures formed by the spontaneous shedding of bacterial outer membrane, and have many components of outer membrane, including outer membrane proteins (OMPs), lipopolysaccharide (LPS), lipids and other protein components. Increasing studies were focusing on the biological function of OMVs in the development of H. pylori infection. Meanwhile, many researches showed that H. pylori OMVs act as vaccine candidate with the potential application in the prevention and treatment of H. pylori infection. Therefore, our review summarized the research progress on the components of OMVs derived from H. pylori, and discussed the potential functions of OMVs in the survival and pathogenesis of H. pylori, as well as the role of OMVs in the treatment of H. pylori infection.