Abstract:The Molecular Enzyme Engineering course is a professional discipline combing the theory and practice. It locates the core position in curriculum provision of bioengineering major postgraduate students and plays an important role in cultivation of professional talents. In order to cater the objective command of professional postgraduate degree development, enhance the innovation of case teaching pattern, promote the practical teaching effect and further improve the postgraduate students’ enthusiasm towards the course as well as cultivate the practical innovation capability, our teaching team investigated the innovation and exploration on the teaching pattern, teaching method as well as teaching technologies for this course by introducing the virtual simulate technology, carrying on the case teaching pattern attempts and utilizing the “Internet plus” technology. In addition, we have obtained some preliminary results and experience for other peers’ reference.