SARS-CoV-2抗原表位分析及相关疫苗研发的进展与挑战

Epitope analysis and vaccine development of severe acute respiratory syndrome coronavirus 2: a review

摘要:

疫苗的接种被认为是阻止时下2019冠状病毒病(Corona Virus Disease 2019，COVID-19)疫情进一步蔓延的最有效手段。目前，国内外多个研究团队采用了不同的技术路线开展严重急性呼吸综合征冠状病毒2 (Severe Acute Respiratory Syndrome Coronavirus 2，SARS-CoV-2)相关疫苗的研发。本文就SARS-CoV-2抗原表位分析、相关疫苗的研究进展以及疫苗接种潜在的风险等多个方面的研究进行综述。评价各研发路线疫苗安全性和有效性的同时，对疫苗发展应用所面临的困难进行讨论。

Abstract:

Vaccination has been considered as the most effective method to prevent the further spread of the current corona virus disease 2019 (COVID-19). Nowadays, many research teams world wide have applied different technologies for the research on the vaccines of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This article summarizes the research on multiple aspects, including epitope analysis of SARS-CoV-2, research progress of vaccines and potential risk of vaccination. It discusses the difficulties in the development and application of vaccines in the meantime of evaluating the safety and effectiveness of the vaccines in the respective research routes.