Abstract:Microbiology as one of the most important subjects of the modern biology is the core curriculum for Biology Science, Food Science, Marine Science, Medical Science and related disciplines. A sound understanding of microbiology is essential for students who are engaged in research or industrial work in the above disciplines. The challenges associated with microbiology learning are the student’s incomplete knowledge network and the lack of initiatives and creativities. We have introduced teaching reform and practice into the teaching of microbiology for inspiring students’ pluralistic interests and individualized talents. By integrating microbiology curriculum with activities that promote student’s interests, such as comics, music, poetry and handcraft etc. to diversifying the course content in order to guide students developing personal interests and understanding on Microbiology. It has been proven that the implementation of the current teaching reformation has aroused the student’s interests and knowledge on Microbiology.