链霉菌转运系统研究进展

Research progress in Streptomyces transport system

摘要:

链霉菌是具有复杂生命周期的革兰氏阳性细菌，其丰富多样的次级代谢产物使得链霉菌成为天然抗生素来源最为广泛的菌株。目前链霉菌研究主要集中在次级代谢和形态分化过程。近年来，因链霉菌转运系统在次级代谢和形态分化等过程中发挥重要作用而得到研究者们的极大关注。链霉菌转运系统不仅能够通过信号转导系统直接参与菌丝体形态分化过程，而且能够运送抗生素等次级代谢产物，使其在链霉菌工业生产方面具有极大的应用前景。除此之外，转运系统作为菌体“第一道门”，能够运送营养物质来改变初级代谢过程，进而影响形态分化和次级代谢等过程，使菌体能迅速适应复杂的环境。因此，链霉菌中转运系统的研究对其形态分化调控通路的阐释具有重要的指导意义。

Abstract:

Streptomyces are gram-positive bacteria with complex life cycle, and considered as the most extensive source of natural antibiotics due to the abundant and diverse secondary metabolites. Current studies on Streptomyces mainly focus on the secondary metabolism and morphological differentiation processes. The transport systems of Streptomyces have raised a lot of attention in recent years due to the important roles in these life processes. The transport systems have a great application prospect in the industrial production for their participation in morphological differentiation process through the signal transduction system and delivery of the secondary metabolites. In addition, as the “first door” of bacteria, transport systems can carry nutrients to regulate the primary metabolic processes, further affecting the processes of morphological differentiation and secondary metabolism, resulting in quick adaptation to the complex environment. Therefore, the studies on the transport systems of Streptomyces can provide important guidance for the interpretation of the regulation pathway of morphological differentiation.