Triterpenoids are one of the main active chemical components in Ganoderma. Because of their many important physiological activities, they have become the research focus of domestic and foreign researcher. In this paper, the optimization of triterpenoid fermentation technology and the progress of signal transduction in the biosynthesis of Ganoderma were summarized, and the problems in the research of Ganoderma fermentation were put forward. The aim of this review is to provide reference and inspiration for the regulation of submerged fermentation of triterpenoids and the development of fermentation technology of Ganoderma.