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希瓦氏菌铁稳态及调控的研究进展
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国家自然科学基金(31930003)


Iron homeostasis and its regulation in Shewanella: a review
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    摘要:

    铁元素通常以蛋白辅因子的形式参与一系列重要的生命过程,是绝大多数生命必需的营养物质。在细菌生命过程中,一方面铁短缺是必须克服的严峻挑战,另一方面铁过量又会危及生命。铁的这种二元性质要求细菌必须严格保持体内的铁稳态。当前革兰氏阴性菌铁稳态的作用模式及理解主要基于肠道细菌大肠杆菌的长期探索成果。近年来,在环境细菌中开展的相关研究揭示了革兰氏阴性菌的铁稳态机制存在出乎意料的多样性:细菌中铁稳态相关的生物途径及组成蛋白、关键调控系统的生理影响以及铁稳态与其他生物过程的相互影响等方面都显示不同菌种的生存和进化特征。本综述以希瓦氏菌中的相关发现为基础,分析总结革兰氏阴性菌铁稳态重要途径及其组成的多样性、不同途径的相互影响以及调控因子的生理影响和调控机理等方面的研究进展和未解决的问题,以期为革兰氏阴性菌铁稳态的研究提供参考。

    Abstract:

    Iron, an essential nutrient for the survival of virtually all living organisms, participates in a variety of important biological processes mainly in the form of protein cofactors. For bacteria, iron shortage is a severe challenge to overcome and iron overload imposes an equally critical threat. The dualistic properties of iron prompt bacterial cells to carefully maintain intracellular iron homeostasis. Current mechanic model for iron homeostasis in gram-negative bacteria is mainly derived from the extensive studies of model bacterium Escherichia coli. In recent years, investigations into iron homeostasis in environmental bacteria have revealed surprising diversities in iron-controlling mechanisms among gram-negative bacteria. With respect to iron homeostasis, the biological pathways and their components, major regulators and their physiological impacts, and interactions between iron homeostasis and other physiological activities display a myriad of species-specific characteristics formed by evolution. This review, stemming from the discoveries in Shewanella, summarizes recent advances about the biological processes involved in iron homeostasis, their reciprocal influences, and physiological consequences of imbalanced iron homeostasis due to altered regulation, as well as lists out the questions to be addressed, aiming at facilitate future explorations in the field of iron homeostasis.

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梁惠惠,冯雪,高海春. 希瓦氏菌铁稳态及调控的研究进展[J]. 微生物学通报, 2020, 47(10): 3305-3317

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  • 在线发布日期: 2020-10-06
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