Abstract:Animal Microbiology is an important basic course for animal husbandry and veterinary medicine in higher vocational school. It is theoretical, technical and practical. Its teaching effect has a significant impact on the students’ follow-up professional learning and practical skills. Starting from the requirements that the course teaching should consider the training of modern professional and technical personnel, this article discusses the necessity of reforming and practicing the Animal Microbiology course. Besides, this article suggests adjusting the teaching hours, to optimize the teaching content, to innovate the teaching methods and the comprehensive use of multiple teaching methods such as multimedia, flipped classroom, integration of theory and practice, etc. Finally, an efficient classroom of Animal Microbiology courses oriented by professional skills is built, and then a practical approach is proposed to train high quality and application-oriented with professional theoretical knowledge and certain practical operational skills.