Corona virus disease 2019 (COVID-19) has been postponed since the outbreak of the new coronavirus pneumonia. However, the suspension of classes has ceased to teach and suspend classes. Teachers of all schools use various network resources to carry out online teaching, which also brings opportunities for further exploring the new teaching mode of “Internet+education”. Taking the application of the cloud textbook of Immunology and Pathogenic Biology as an example, this paper discusses how to create a reasonable learning situation by using the mobile interactive digital textbook, so as to realize the interactive learning and improve the teaching effect of online learning.