羧酸还原酶的研究进展

Recent advances in carboxylic acid reductases

摘要:

羧酸还原酶(carboxylic acid reductases，CARs)可以催化羧酸还原为相应的醛，反应条件温和、拥有广阔的底物范围且副反应较少。本文旨在综述近年来羧酸还原酶系统发育、结构与催化机理、蛋白质工程和固定化工程等方面的研究成果，揭示其作为重要工具酶在生物转化及合成生物学中的应用前景。

Abstract:

Carboxylic acid reductases (CARs) are capable of reducing carboxylic acids to the respective aldehydes under mild conditions, and have a broad substrate scope with no side products. Herein, we summarize recent advances in the research of phylogeny divergence, protein structure, catalytic mechanism and protein engineering of CARs, revealing its application prospect as an important tool enzyme in biological transformation and synthetic biology.