Abstract:Innovation and entrepreneurship education has become an important orientation in the reform of national higher education. How to combine curriculum reform with innovation and entrepreneurship education is a crucial subject in Microbiology teaching. In that project, several measures were taken to cultivate students? innovative ability and entrepreneurial thinking. Firstly, participation in experimental preparation of interest group enabled some students to rapidly grow into experimental experts. This practice had become a good inheritance and characteristics of Microbiology curriculum, which had been widely used in other courses in our university. Secondly, the students? ability of comprehensive application of knowledge, scientific research thinking and innovation could be improved by the modular experiments with diversified designing, so that students could step on the scientific research road in the process of subtle influence. Thirdly, guiding students to participate in the teacher?s project and applying for the discipline competition project could cultivate students’ scientific research thinking and experimental skills, which was a beneficial extension of practical teaching. The above reform had achieved remarkable results. The activity of studying and participating in scientific research of the students had been significantly improved. The quality and number of scientific research projects applied by students remarkably increased. Those students also did well in academic competitions, scientific paper publishing, and patent applications. This mode played an important role in improving the undergraduates? innovation and entrepreneurship ability, as well as comprehensive capability, which could be applied in talent training in other local universities.